| Salford | Rebecca Long Bailey | Labour | 7 May 2015 |
| Salisbury | John Glen | Conservative | 6 May 2010 |
| Scarborough and Whitby | Alison Hume | Labour | 4 July 2024 |
| Scunthorpe | Sir Nicholas Dakin | Labour | 4 July 2024 |
| Sefton Central | Bill Esterson | Labour | 6 May 2010 |
| Selby | Keir Mather | Labour | 20 July 2023 |
| Sevenoaks | Laura Trott | Conservative | 12 December 2019 |
| Sheffield Brightside and Hillsborough | Gill Furniss | Labour | 5 May 2016 |
| Sheffield Central | Abtisam Mohamed | Labour | 4 July 2024 |
| Sheffield Hallam | Olivia Blake | Labour | 12 December 2019 |
| Sheffield Heeley | Louise Haigh | Labour | 7 May 2015 |
| Sheffield South East | Mr Clive Betts | Labour | 9 April 1992 |
| Sherwood Forest | Michelle Welsh | Labour | 4 July 2024 |
| Shipley | Anna Dixon | Labour | 4 July 2024 |
| Shrewsbury | Julia Buckley | Labour | 4 July 2024 |
| Sittingbourne and Sheppey | Kevin McKenna | Labour | 4 July 2024 |
| Skipton and Ripon | Sir Julian Smith | Conservative | 6 May 2010 |
| Sleaford and North Hykeham | Dr Caroline Johnson | Conservative | 8 December 2016 |
| Slough | Mr Tanmanjeet Singh Dhesi | Labour | 8 June 2017 |
| Smethwick | Gurinder Singh Josan | Labour | 4 July 2024 |
| Solihull West and Shirley | Dr Neil Shastri-Hurst | Conservative | 4 July 2024 |
| South Antrim | Robin Swann | Ulster Unionist Party | 4 July 2024 |
| South Basildon and East Thurrock | James McMurdock | Independent | 4 July 2024 |
| South Cambridgeshire | Pippa Heylings | Liberal Democrat | 4 July 2024 |
| South Cotswolds | Dr Roz Savage | Liberal Democrat | 4 July 2024 |
| South Derbyshire | Samantha Niblett | Labour | 4 July 2024 |
| South Devon | Caroline Voaden | Liberal Democrat | 4 July 2024 |
| South Dorset | Lloyd Hatton | Labour | 4 July 2024 |
| South Down | Chris Hazzard | Sinn Féin | 8 June 2017 |
| South East Cornwall | Anna Gelderd | Labour | 4 July 2024 |
| South Holland and The Deepings | Sir John Hayes | Conservative | 1 May 1997 |
| South Leicestershire | Alberto Costa | Conservative | 7 May 2015 |
| South Norfolk | Ben Goldsborough | Labour | 4 July 2024 |
| South Northamptonshire | Sarah Bool | Conservative | 4 July 2024 |
| South Ribble | Mr Paul Foster | Labour | 4 July 2024 |
| South Shields | Emma Lewell | Labour | 2 May 2013 |
| South Shropshire | Stuart Anderson | Conservative | 12 December 2019 |
| South Suffolk | James Cartlidge | Conservative | 7 May 2015 |
| South West Devon | Rebecca Smith | Conservative | 4 July 2024 |
| South West Hertfordshire | Mr Gagan Mohindra | Conservative | 12 December 2019 |
| South West Norfolk | Terry Jermy | Labour | 4 July 2024 |
| South West Wiltshire | Dr Andrew Murrison | Conservative | 7 June 2001 |
| Southampton Itchen | Darren Paffey | Labour | 4 July 2024 |
| Southampton Test | Satvir Kaur | Labour | 4 July 2024 |
| Southend East and Rochford | Mr Bayo Alaba | Independent | 4 July 2024 |
| Southend West and Leigh | David Burton-Sampson | Labour | 4 July 2024 |
| Southgate and Wood Green | Bambos Charalambous | Labour | 8 June 2017 |
| Southport | Patrick Hurley | Labour | 4 July 2024 |
| Spelthorne | Lincoln Jopp | Conservative | 4 July 2024 |
| Spen Valley | Kim Leadbeater | Labour | 1 July 2021 |
| St Albans | Daisy Cooper | Liberal Democrat | 12 December 2019 |
| St Austell and Newquay | Noah Law | Labour | 4 July 2024 |
| St Helens North | David Baines | Labour | 4 July 2024 |
| St Helens South and Whiston | Ms Marie Rimmer | Labour | 7 May 2015 |
| St Ives | Andrew George | Liberal Democrat | 4 July 2024 |
| St Neots and Mid Cambridgeshire | Ian Sollom | Liberal Democrat | 4 July 2024 |
| Stafford | Leigh Ingham | Labour | 4 July 2024 |
| Staffordshire Moorlands | Dame Karen Bradley | Conservative | 6 May 2010 |
| Stalybridge and Hyde | Jonathan Reynolds | Labour (Co-op) | 6 May 2010 |
| Stevenage | Kevin Bonavia | Labour | 4 July 2024 |
| Stirling and Strathallan | Chris Kane | Labour | 4 July 2024 |
| Stockport | Navendu Mishra | Labour | 12 December 2019 |
| Stockton North | Chris McDonald | Labour | 4 July 2024 |
| Stockton West | Matt Vickers | Conservative | 12 December 2019 |
| Stoke-on-Trent Central | Gareth Snell | Labour (Co-op) | 4 July 2024 |
| Stoke-on-Trent North | David Williams | Labour | 4 July 2024 |
| Stoke-on-Trent South | Dr Allison Gardner | Labour | 4 July 2024 |
| Stone, Great Wyrley and Penkridge | Sir Gavin Williamson | Conservative | 6 May 2010 |
| Stourbridge | Cat Eccles | Labour | 4 July 2024 |
| Strangford | Jim Shannon | Democratic Unionist Party | 6 May 2010 |
| Stratford and Bow | Uma Kumaran | Labour | 4 July 2024 |
| Stratford-on-Avon | Manuela Perteghella | Liberal Democrat | 4 July 2024 |
| Streatham and Croydon North | Steve Reed | Labour (Co-op) | 29 November 2012 |
| Stretford and Urmston | Andrew Western | Labour | 15 December 2022 |
| Stroud | Dr Simon Opher | Labour | 4 July 2024 |
| Suffolk Coastal | Jenny Riddell-Carpenter | Labour | 4 July 2024 |
| Sunderland Central | Lewis Atkinson | Labour | 4 July 2024 |
| Surrey Heath | Dr Al Pinkerton | Liberal Democrat | 4 July 2024 |
| Sussex Weald | Ms Nusrat Ghani | Conservative | 7 May 2015 |
| Sutton and Cheam | Luke Taylor | Liberal Democrat | 4 July 2024 |
| Sutton Coldfield | Sir Andrew Mitchell | Conservative | 7 June 2001 |
| Swansea West | Torsten Bell | Labour | 4 July 2024 |
| Swindon North | Will Stone | Labour | 4 July 2024 |
| Swindon South | Heidi Alexander | Labour | 4 July 2024 |